Concepedia

Bioisosteric replacement of dihydropyrazole of 4S-(−)-3-(4-chlorophenyl)-N-methyl-N′-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole

Brijesh Kumar Srivastava, Rina Soni, Amit Joharapurkar, K Sairam, Jayendra Z. Patel, Amitgiri Goswami, Sandeep A. Shedage, Sidhartha S. Kar, Rahul P. Salunke, Shivaji B. Gugale,

Bioorganic & Medicinal Chemistry Letters · 2007 · 13 citations · 14 references

DOI

Concepts

References

14

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

, , +17

Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors

M. Arnone, Jeanne Maruani, Frédérique Chaperon et al. · Psychopharmacology · 1997 · 595 citations

, , +13

An Alternative Procedure for the Aluminum-Mediated Conversion of Esters to Amides

Jeremy I. Levin, Edward Turos, Steven M. Weinreb · Synthetic Communications · 1982 · 384 citations

, , +3

Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB<sub>1</sub> Cannabinoid Receptor Antagonists

Jos H.M. Lange, Hein K. A. C. Coolen, Herman H. van Stuivenberg et al. · Journal of Medicinal Chemistry · 2003 · 188 citations · Full text

, , +17

Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant:  Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB<sub>1</sub>Cannabinoid Receptor Antagonists

Jos H.M. Lange, Herman H. van Stuivenberg, Hein K. A. C. Coolen et al. · Journal of Medicinal Chemistry · 2004 · 179 citations · Full text

, , +17