Jos H.M. Lange

Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB₁ Cannabinoid Receptor Antagonists

Jos H.M. Lange, Hein K. A. C. Coolen, Herman H. van Stuivenberg et al. · Journal of Medicinal Chemistry · 2003 · 186 citations · Full text

Drug Target, Biological Properties, X-ray Diffraction Study +21

Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant:  Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB₁Cannabinoid Receptor Antagonists

Jos H.M. Lange, Herman H. van Stuivenberg, Hein K. A. C. Coolen et al. · Journal of Medicinal Chemistry · 2004 · 177 citations · Full text

Pyrazole Series, Organic Chemistry, Pharmacotherapy +19

Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity

Antoni R. Blaazer, Jos H.M. Lange, Martina A.W. van der Neut et al. · European Journal of Medicinal Chemistry · 2011 · 72 citations · Full text

Cannabis Use, Psychoactive Drug, Biochemistry +12

Ruphos-mediated Suzuki cross-coupling of secondary alkyl trifluoroborates

Adri van den Hoogenband, Jos H.M. Lange, Jan Willem Terpstra et al. · Tetrahedron Letters · 2008 · 70 citations · Full text

Organic Chemistry, Cross-coupling Reaction, Chemistry +1

Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions

Jos H.M. Lange, Peter C. Verveer, Stefan J. M. Osnabrug et al. · Tetrahedron Letters · 2001 · 68 citations

Rapid Microwave-enhanced Synthesis, Organic Chemistry, Synthesis Method +3