Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19

Improved method for high efficiency transformation of intact yeast cells

Daniel Gietz, Andrew St. Jean, Robin A. Woods et al. · Nucleic Acids Research · 1992 · 3.3K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +7

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Richard M. Weinshilboum, S. L. Sladek · PubMed · 1980 · 1.2K citations

Veterinary Medicine, Genetics, Pharmacology +13

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance

Charles R. Yates, Eugene Y. Krynetski, Thrina Loennechen et al. · Annals of Internal Medicine · 1997 · 763 citations

Life Sciences, Genetics, Pharmacology +13

Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism

Lynne Lennard, Jon A. Van Loon, Richard M. Weinshilboum · Clinical Pharmacology & Therapeutics · 1989 · 600 citations

Medicine, Pharmacology, Drug Metabolism +12

Comprehensive analysis of thiopurine S-methyltransferase phenotype–genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

Elke Schaeffeler, Christine Fischer, D. Brockmeier et al. · Pharmacogenetics · 2004 · 420 citations

Life Sciences, Genetics, Pharmacology +14