Bioorganic & Medicinal Chemistry Letters · 2011 · 85 citations · 9 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryLead OptimizationFragment-based Drug DesignFragment-based Lead DiscoveryFragment-based OptimizationLigand BindingMolecular DockingProtein-ligand DockingFragment OptimizationFragment-based De Novo DesignFragment-based DiscoveryFragment-based Ligand DesignFragment-based Virtual Screening
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Site-directed ligand discovery
Daniel A. Erlanson, Andrew C. Braisted, D.R. Raphael et al. · Proceedings of the National Academy of Sciences · 2000 · 466 citations
Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1
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In situ assembly of enzyme inhibitors using extended tethering
Daniel A. Erlanson, Joni W. Lam, Christian Wiesmann et al. · Nature Biotechnology · 2003 · 200 citations
Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells
Kumiko Nagashima, Stuart D. Shumway, Sriram Sathyanarayanan et al. · Journal of Biological Chemistry · 2010 · 66 citations · Full text
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