Stuart D. Shumway

An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies

Jennifer O’Neil, Yair Benita, Igor Feldman et al. · Molecular Cancer Therapeutics · 2016 · 410 citations

Drug Target, Combination Drug Therapy, Tumor Biology +17

Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1

Marieke Aarts, Rachel Sharpe, Isaac García-Murillas et al. · Cancer Discovery · 2012 · 320 citations

Cell Death, Cytoskeleton, Cell Cycle +24

MK-1775, a Potent Wee1 Inhibitor, Synergizes with Gemcitabine to Achieve Tumor Regressions, Selectively in p53-Deficient Pancreatic Cancer Xenografts

N.V. Rajeshkumar, Elizabeth De Oliveira, Niki A. Ottenhof et al. · Clinical Cancer Research · 2011 · 274 citations · Full text

Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases

Seth J. Goldenberg, Thomas C. Cascio, Stuart D. Shumway et al. · Cell · 2004 · 274 citations · Full text

Protein Function, Protein Assembly, Molecular Regulation +6

Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors

Suzanne Leijen, Robin M.J.M. van Geel, Anna C. Pavlick et al. · Journal of Clinical Oncology · 2016 · 263 citations · Full text