Seth J. Goldenberg

Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling

Michael B. Major, Nathan D. Camp, Jason D. Berndt et al. · Science · 2007 · 410 citations

Signal Transduction, Protein Interaction Network, Signaling Pathway +12

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

Mikael Altun, Holger Kramer, Lianne I. Willems et al. · Chemistry & Biology · 2011 · 389 citations

Proteomic Technology, Biochemistry, Natural Sciences +4

The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation

Stéphane Angers, Chris J. Thorpe, Travis L. Biechele et al. · Nature Cell Biology · 2006 · 353 citations

Signal Transduction, Signaling Pathway, Molecular Pathway +12

Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases

Seth J. Goldenberg, Thomas C. Cascio, Stuart D. Shumway et al. · Cell · 2004 · 274 citations · Full text

Protein Function, Protein Assembly, Molecular Regulation +6

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47

Joseph Weinstock, Jian Wu, Ping Cao et al. · ACS Medicinal Chemistry Letters · 2012 · 184 citations · Full text

Molecular Biology, Cancer Biology, Pharmaceutical Chemistry +21