High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

Traver Hart, Megha Chandrashekhar, Michael Aregger, +15

Cell

Genotype-specific Cancer LiabilitiesEngineeringGeneticsGenetic EngineeringMolecular Genetics +7

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

Ji‐Young Youn, Wade H. Dunham, Seo Jung Hong, +12

Molecular Cell

Subcellular OrganizationMedicineNatural SciencesRna Structure PredictionMolecular Biology +10

Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery

Stéphane Angers, Ti Li, Xianhua Yi, +3

Nature

Protein FunctionProtein AssemblyNatural SciencesMacromolecular MachineMolecular Biology +4

Detection of β ₂ -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

Stéphane Angers, Ali Salahpour, Éric Joly, +4

Proceedings of the National Academy of Sciences

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

Jean-Pierre Morello, Ali Salahpour, André Laperrière, +8

Journal of Clinical Investigation

V2 Vasopressin ReceptorCellular PhysiologyMolecular PharmacologyCell SurfaceChaperones +17

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

Henner F. Farin, Ingrid Jordens, Mohammed H. Mosa, +8

Nature

Cell LineageDevelopmental BiologyMedicineAdult Stem CellGut-organ Axis +6

β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

Mounia Azzi, Pascale G. Charest, Stéphane Angers, +4

Proceedings of the National Academy of Sciences

Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer

Jean‐François Mercier, Ali Salahpour, Stéphane Angers, +2

Journal of Biological Chemistry

β2-Adrenergic Receptor Homo-Cellular PhysiologyMolecular PharmacologyReceptor DimerizationCell Signaling +18

Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling

Michael B. Major, Nathan D. Camp, Jason D. Berndt, +9

Science

Signal TransductionProtein Interaction NetworkSignaling PathwayMolecular PathwayMedicine +10

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Michal Zimmermann, Olga Murina, Martin A.M. Reijns, +21

Nature

Natural SciencesGeneticsParp-trapping LesionsMolecular BiologyDna Replication +8