Joni W. Lam

Discovery of an allosteric site in the caspases

Jeanne A. Hardy, Joni W. Lam, Jack Nguyen et al. · Proceedings of the National Academy of Sciences · 2004 · 241 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

In situ assembly of enzyme inhibitors using extended tethering

Daniel A. Erlanson, Joni W. Lam, Christian Wiesmann et al. · Nature Biotechnology · 2003 · 200 citations

Life Sciences, Biochemistry, Molecular Biology +14

Discovery of a potent and selective Aurora kinase inhibitor

Johan D. Oslob, M.J. Romanowski, Darin A. Allen et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 108 citations · Full text

Medicine, Medicinal Chemistry, Oncology +9

Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design

Ingrid Choong, Willard Lew, Dennis Lee et al. · Journal of Medicinal Chemistry · 2002 · 105 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo

Jennifer P. Arbitrario, Brian J. Belmont, Marc Evanchik et al. · Cancer Chemotherapy and Pharmacology · 2009 · 67 citations

Medicine, Oncology, Pharmacology +9