Marc Evanchik

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Eric M. Green, Hiroko Wakimoto, Robert L. Anderson et al. · Science · 2016 · 709 citations · Full text

Medicine, Cardiology, Pharmacology +15

A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy

Joshua A. Stern, Svetlana Markova, Yu Ueda et al. · PLoS ONE · 2016 · 128 citations · Full text

Medicine, Cardiology, Pharmacology +13

<i>In vitro</i>and<i>in vivo</i>pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin

Mark P. Grillo, John C. L. Erve, Ryan A. Dick et al. · Xenobiotica · 2018 · 104 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye

Min Zhong, Thomas R. Gadek, Minna Bui et al. · ACS Medicinal Chemistry Letters · 2012 · 97 citations · Full text

Medicine, Immunology, Ophthalmology +17

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo

Jennifer P. Arbitrario, Brian J. Belmont, Marc Evanchik et al. · Cancer Chemotherapy and Pharmacology · 2009 · 67 citations

Medicine, Oncology, Pharmacology +9