Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

Erik Verner, B.A. Katz, Jeffrey R. Spencer, +17

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistrySerine Protease InhibitorsChemical BiologyNovel Scaffolds +17

Discovery of a potent and selective Aurora kinase inhibitor

Johan D. Oslob, M.J. Romanowski, Darin A. Allen, +25

Bioorganic & Medicinal Chemistry Letters

Signaling PathwayReceptor Tyrosine KinaseMedicineCell BiologyCell Signaling +2

Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design

Ingrid Choong, Willard Lew, Dennis Lee, +12

Journal of Medicinal Chemistry

Drug TargetChemical BiologyInitial Tethering HitPharmaceutical ChemistryMedicinal Chemistry +15

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

B.A. Katz, Paul A. Sprengeler, Christine Luong, +11

Chemistry & Biology

Protease InhibitorsProtein FunctionDrug TargetDrug TargetingBiochemistry +8

2-Aminobenzimidazoles as potent Aurora kinase inhibitors

Min Zhong, Minna Bui, Shen Wang, +26

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacotherapyAnti-cancer AgentPharmacology +3

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors

B.A. Katz, Kyle Elrod, Erik Verner, +12

Journal of Molecular Biology

Protein ChemistryProtein AssemblyBiochemistryProtein FoldingNatural Sciences +6

Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent

Marc Evanchik, Darin A. Allen, Josh C. Yoburn, +2

Drug Metabolism and Disposition

Identification of potent and novel small-Molecule inhibitors of caspase-3

Darin A. Allen, Phuongly Pham, Ingrid Choong, +8

Bioorganic & Medicinal Chemistry Letters

Drug TargetMedicineNovel Small-molecule InhibitorsPharmacologyNovel Therapy +2

4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Jeffrey R. Spencer, D. P. C. MCGEE, Darin A. Allen, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +7

Water-soluble prodrugs of an Aurora kinase inhibitor

Johan D. Oslob, Stacey A. Heumann, Chul H. Yu, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceMedicineAurora Kinase InhibitorAnti-cancer Agent +3