Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel, +44

Nature Cell Biology

InflammationCell AutophagySignal TransductionHeme HomeostasisIron Metabolism +11

Discovery of a potent and selective Aurora kinase inhibitor

Johan D. Oslob, M.J. Romanowski, Darin A. Allen, +25

Bioorganic & Medicinal Chemistry Letters

Signaling PathwayReceptor Tyrosine KinaseMedicineCell BiologyCell Signaling +2

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Daniel A. Erlanson, Joseph W. Arndt, Mark T. Cancilla, +23

Bioorganic & Medicinal Chemistry Letters

Molecular DockingFragment-based Drug DiscoveryDrug TargetBiochemistrySelective Pdk1 Inhibitor +4

Structure of <i>Toxoplasma gondii </i>LDH1:  Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD⁺ Use^,

K.L. Kavanagh, R.A. Elling, David K. Wilson

Biochemistry

Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies

Eric di Luccio, R.A. Elling, David K. Wilson

Biochemical Journal

Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism

Dustin Dovala, Christopher M. Rath, Qijun Hu, +5

Proceedings of the National Academy of Sciences

Structure-Guided Engineering of Xylitol Dehydrogenase Cosubstrate Specificity

Andreas H. Ehrensberger, R.A. Elling, David K. Wilson

Structure

BiosynthesisEngineeringBiochemistryNatural SciencesEnzyme Catalysis +5

Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-<i>a</i>]pyrazines as ATR Inhibitors

Paul A. Barsanti, Robert J. Aversa, Xianming Jin, +13

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceDrug TargetNovel PotentPharmacotherapyAtr Inhibitors +18

2-Aminobenzimidazoles as potent Aurora kinase inhibitors

Min Zhong, Minna Bui, Shen Wang, +26

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacotherapyAnti-cancer AgentPharmacology +3

Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors

Yipin Lu, Mark Knapp, Kenneth Crawford, +16

Journal of Molecular Biology

Molecular PharmacologyPikk FamilyProtein FunctionSignal TransductionBiochemistry +13