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Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn

Tyr188leu MutantInhibitor FlexibilityHuman RetrovirusAntiviral Drug DevelopmentDrug Resistance 1Molecular BiologyResistance Mutation (Virology)Antiviral DrugHivBiomolecular EngineeringMedicineAntiviral CompoundStructural BiologyDrug Discovery