Arthur D. Clark

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

Alfredo Jacobo‐Molina, Jianping Ding, Raymond G. Nanni et al. · Proceedings of the National Academy of Sciences · 1993 · 1.1K citations · Full text

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Kalyan Das, Arthur D. Clark, Paul Lewi et al. · Journal of Medicinal Chemistry · 2004 · 511 citations

Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

Stefan G. Sarafianos, Kalyan Das, Chris Tantillo et al. · The EMBO Journal · 2001 · 403 citations · Full text

Polypurine Tract Rna, Virus Structure, Viral Replication +12

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

Kalyan Das, Joseph D. Bauman, Arthur D. Clark et al. · Proceedings of the National Academy of Sciences · 2008 · 335 citations · Full text

Viral Replication, Engineering, Molecular Biology +21

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution

Jianping Ding, Kalyan Das, Y. Hsiou et al. · Journal of Molecular Biology · 1998 · 322 citations

Virus Structure, Viral Replication, Viral Polymerase Structure +12