Joseph D. Bauman

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

Kalyan Das, Joseph D. Bauman, Arthur D. Clark et al. · Proceedings of the National Academy of Sciences · 2008 · 335 citations · Full text

Viral Replication, Engineering, Molecular Biology +21

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism

Kalyan Das, Sergio E. Martinez, Joseph D. Bauman et al. · Nature Structural & Molecular Biology · 2012 · 192 citations · Full text

Natural Sciences, Human Retrovirus, Antiviral Drug Development +10

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

D.M. Himmel, Karen A. Maegley, Tom Pauly et al. · Structure · 2009 · 142 citations · Full text

Virus Structure, Viral Replication, Viral Polymerase Structure +10

Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase

Chong Fang, Joseph D. Bauman, Kalyan Das et al. · Proceedings of the National Academy of Sciences · 2007 · 136 citations · Full text

Chemical Biology, Nonnucleoside Inhibitor Tmc278, Cyanovinyl Arm +13

Structural basis of HIV-1 resistance to AZT by excision

Xiongying Tu, Kalyan Das, Qianwei Han et al. · Nature Structural & Molecular Biology · 2010 · 119 citations · Full text

Hiv-1 Resistance, Human Retrovirus, Immunology +7