Porphyrin sponges: conservative of host structure in over 200 porphyrin-based lattice clathrates

Marianne P. Byrn, Carol J. Curtis, Y. Hsiou, +5

Journal of the American Chemical Society

Molecular SciencesEngineeringBiochemistryPhysicochemical AnalysisHost Structure +12

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution

Jianping Ding, Kalyan Das, Y. Hsiou, +5

Journal of Molecular Biology

Virus StructureViral ReplicationViral Polymerase StructureBiochemistryNatural Sciences +10

Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms

Y. Hsiou, Jianping Ding, Kalyan Das, +3

Structure

Virus StructureViral ReplicationBiochemistryProtein FoldingNatural Sciences +11

Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

Jianping Ding, Kalyan Das, Chris Tantillo, +15

Structure

Virus StructureViral ReplicationViral Polymerase StructureHuman RetrovirusViral Polymerase Mechanism +7

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

Y. Hsiou, Jianping Ding, Kalyan Das, +7

Journal of Molecular Biology

Lys103asn MutationHuman RetrovirusHiv-1 RtImmunologyAntiviral Response +8

Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant

Kalyan Das, Jianping Ding, Y. Hsiou, +12

Journal of Molecular Biology

Wild-type Hiv-1 RtBiochemistry9-Cl Tibo ComplexedNatural SciencesHuman Retrovirus +10

Porphyrin sponges: structural systematics of the host lattice

Marianne P. Byrn, Carol J. Curtis, Israel Goldberg, +5

Journal of the American Chemical Society

EngineeringChemical AnalysisAltmetric Attention ScoreOrganic ChemistryChemistry +14

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn

Y. Hsiou, Kalyan Das, Jianping Ding, +6

Journal of Molecular Biology

Tyr188leu MutantInhibitor FlexibilityHuman RetrovirusAntiviral Drug DevelopmentDrug Resistance 1 +9

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

J P Kleim, Manfred Rösner, Irvin Winkler, +5

Proceedings of the National Academy of Sciences

Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates

John W. Mellors, Hengameh Z. Bazmi, Raymond F. Schinazi, +5

Antimicrobial Agents and Chemotherapy