Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms

The CCP4 suite: programs for protein crystallography

Number Collaborative Computational Project · Acta Crystallographica Section D Biological Crystallography · 1994 · 17.3K citations

Life Sciences, Biochemistry, Biophysics +15

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.7K citations

Life Sciences, Biochemistry, Biomolecular Modeling +16

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

Lori A. Kohlstaedt, J Wang, Jonathan M. Friedman et al. · Science · 1992 · 1.9K citations

Life Sciences, Biochemistry, Molecular Biology +17

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

Alfredo Jacobo‐Molina, Jianping Ding, Raymond G. Nanni et al. · Proceedings of the National Academy of Sciences · 1993 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +17

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Nonnucleoside Inhibitors

Rebecca Spence, Warren M. Kati, Karen S. Anderson et al. · Science · 1995 · 522 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17