G Riess

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn

Y. Hsiou, Kalyan Das, Jianping Ding et al. · Journal of Molecular Biology · 1998 · 123 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication

J P Kleim, R. Bender, U M Billhardt et al. · Antimicrobial Agents and Chemotherapy · 1993 · 115 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

J P Kleim, Manfred Rösner, Irvin Winkler et al. · Proceedings of the National Academy of Sciences · 1996 · 83 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720

Jan Balzarini, Anna Karlsson, C Meichsner et al. · Journal of Virology · 1994 · 44 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Heterologous expression of the alpha-amylase inhibitor gene cloned from an amplified genomic sequence of Streptomyces tendae

Klaus-P. Koller, G Riess · Journal of Bacteriology · 1989 · 36 citations · Full text

Life Sciences, Microbiology, Molecular Biology +15