Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication

J P Kleim, R. Bender, U M Billhardt, +5

Antimicrobial Agents and Chemotherapy

Viral ReplicationImmunologyPharmacotherapyAntiviral DrugDrug Resistance +15

Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication

J P Kleim, R. Bender, Reinhard Kirsch, +7

Antimicrobial Agents and Chemotherapy

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

J P Kleim, Manfred Rösner, Irvin Winkler, +5

Proceedings of the National Academy of Sciences

Diagnosis of acute and latent varicella‐zoster virus infections using the polymerase chain reaction

Dorothea Dlugosch, Anna M. Eis‐Hübinger, J P Kleim, +3

Journal of Medical Virology

Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720

Jan Balzarini, Anna Karlsson, C Meichsner, +4

Journal of Virology

Viral ReplicationQuinoxaline S-2720ImmunologyMutant Hiv-1 StrainsPharmacotherapy +19

Graded cytopathogenicity of the human immunodeficiency virus (HIV) in the course of HIV infection

K. E. Schneweis, J P Kleim, E. Bailly, +3

Medical Microbiology and Immunology

Primary ImmunodeficiencyHuman RetrovirusImmunologyHiv InfectionAntiviral Response +6

Rational Dose Selection for a Nonnucleoside Reverse Transcriptase Inhibitor through Use of Population Pharmacokinetic Modeling and Monte Carlo Simulation

George L. Drusano, Katy H. P. Moore, J P Kleim, +2

Antimicrobial Agents and Chemotherapy

Epidemiologically Closely Related Viruses From Hemophilia B Patients Display High Homology in Two Hypervariable Regions of the HIV-1 <i>env</i> Gene

J P Kleim, A. Ackermann, H.‐H. Brackmann, +2

AIDS Research and Human Retroviruses

Comparison of different methods for detecting human immune deficiency virus in human immunodeficiency virus‐seropositive hemophiliacs

K. E. Schneweis, A. Ackermann, A. Friedrich, +4

Journal of Medical Virology

Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1

Heidi Pelemans, Robert Esnouf, A Dunkler, +6

Journal of Virology

ImmunologyVal106ala MutationSelective PressureAntiviral DrugDrug Resistance +15