J P Kleim

Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication

J P Kleim, R. Bender, U M Billhardt et al. · Antimicrobial Agents and Chemotherapy · 1993 · 115 citations · Full text

Viral Replication, Immunology, Pharmacotherapy +17

Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication

J P Kleim, R. Bender, Reinhard Kirsch et al. · Antimicrobial Agents and Chemotherapy · 1995 · 85 citations · Full text

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

J P Kleim, Manfred Rösner, Irvin Winkler et al. · Proceedings of the National Academy of Sciences · 1996 · 83 citations

Diagnosis of acute and latent varicella‐zoster virus infections using the polymerase chain reaction

Dorothea Dlugosch, Anna M. Eis‐Hübinger, J P Kleim et al. · Journal of Medical Virology · 1991 · 58 citations

Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720

Jan Balzarini, Anna Karlsson, C Meichsner et al. · Journal of Virology · 1994 · 44 citations · Full text

Viral Replication, Quinoxaline S-2720, Immunology +21