Manfred Rösner

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

Y. Hsiou, Jianping Ding, Kalyan Das et al. · Journal of Molecular Biology · 2001 · 195 citations

Life Sciences, Genetics, Molecular Biology +16

Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn

Y. Hsiou, Kalyan Das, Jianping Ding et al. · Journal of Molecular Biology · 1998 · 123 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication

J P Kleim, R. Bender, U M Billhardt et al. · Antimicrobial Agents and Chemotherapy · 1993 · 115 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication

J P Kleim, R. Bender, Reinhard Kirsch et al. · Antimicrobial Agents and Chemotherapy · 1995 · 85 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

J P Kleim, Manfred Rösner, Irvin Winkler et al. · Proceedings of the National Academy of Sciences · 1996 · 83 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17