Concepedia

Structural Basis Of Resistance

Structural Basis of Resistance is a scientific concept that identifies the specific molecular and atomic-level alterations in viral proteins or drug-target interfaces that confer resistance to antiviral agents by modulating drug binding or target function.

382

Publications

22.6K

Citations

1.8K

Authors

564

Institutions

Publications per year

2017–2026

75

Parents

Publications

382

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

Huifang Huang, Rajiv Chopra, Gregory L. Verdine et al. · Science · 1998 · 1.4K citations

, , +17

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

Patrick Collins, L.F. Haire, Yi Pu Lin et al. · Nature · 2008 · 537 citations

, , +14

Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1

Z.L. Johnson, Jue Chen · Cell · 2017 · 395 citations · Full text

, , +14

Phenotypic Mechanism of HIV-1 Resistance to 3‘-Azido-3‘-deoxythymidine (AZT):  Increased Polymerization Processivity and Enhanced Sensitivity to Pyrophosphate of the Mutant Viral Reverse Transcriptase

Dominique Arion, Neerja Kaushik, Suzanne McCormick et al. · Biochemistry · 1998 · 339 citations

, , +17

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids

Stefan G. Sarafianos, Kalyan Das, Arthur D. Clark et al. · Proceedings of the National Academy of Sciences · 1999 · 306 citations · Full text

, , +17

1–5 of 382

Authors

1.8K

  1. CA
    Celia A. Schiffer

    University of Massachusetts Chan Medical School, United States

    22 publications · 1.3K citations

    21

    h-index

  2. IT
    Irene T. Weber

    Georgia State University, United States

    18 publications · 1.3K citations

    17

    h-index

  3. RW
    Robert W. Harrison

    Georgia State University, United States

    16 publications · 1.1K citations

    15

    h-index

  4. SH
    Stephen H. Hughes

    National Cancer Institute, United States

    12 publications · 1.3K citations

    12

    h-index

  5. NK
    Neşe Kurt Yılmaz

    University of Massachusetts Chan Medical School, United States

    11 publications · 443 citations

    11

    h-index

1–5 of 1.8K

Institutions

564

  1. National Cancer Institute

    Bethesda, United States

    21 h-index

    77 publications

    6.8K citations

  2. University of Massachusetts Chan Medical School

    Worcester, United States

    21 h-index

    134 publications

    8K citations

  3. National Institutes of Health

    Bethesda, United States

    20 h-index

    89 publications

    8.7K citations

  4. Georgia State University

    Atlanta, United States

    17 h-index

    88 publications

    6K citations

  5. University of Oxford

    Oxford, United Kingdom

    12 h-index

    65 publications

    7.9K citations

  6. Frederick National Laboratory for Cancer Research

    Frederick, United States

    12 h-index

    35 publications

    1.9K citations

  7. Rutgers, The State University of New Jersey

    New Brunswick, United States

    11 h-index

    68 publications

    8.3K citations

  8. Chinese Academy of Sciences

    Beijing, China

    9 h-index

    34 publications

    945 citations

1–8 of 564

Venues

  1. Journal of Virology

    JVI · 34 publications · 2.1K citations

    28

    h-index

  2. Journal of Molecular Biology

    JMB · 18 publications · 1.3K citations

    17

    h-index

  3. Journal of Medicinal Chemistry

    18 publications · 995 citations

    16

    h-index

  4. Biochemistry

    15 publications · 1.2K citations

    15

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 1.9K citations

    12

    h-index

1–5