Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells

Abstract

Both thymus and bone marrow cells of adult mice can be made specifically unresponsive to human gamma globulin, but each cell population displays a distinct kinetic pattern for both the induction and spontaneous loss of the unresponsive state. These kinetics appear to be much slower in the bone marrow cells than in the thymus cells. In addition, the dose of deaggregated human gamma globulin needed to induce unresponsiveness in bone marrow cells is much greater than that needed to induce unresponsiveness in thymus cells. Apparently, unresponsiveness in only one cell type is sufficient for the tolerant state to be exhibited by the intact animal.