Concepedia

Central Tolerance

Central Tolerance is a mechanism of immunological tolerance established during lymphocyte development in primary lymphoid organs, whereby self-reactive T and B cells are selectively eliminated or functionally inactivated to prevent autoimmunity.

343

Publications

24.4K

Citations

1.6K

Authors

473

Institutions

Publications per year

2017–2026

46

Parents

Children

Publications

343

T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation

Ming O. Li, Yisong Y. Wan, Richard A. Flavell · Immunity · 2007 · 716 citations · Full text

, , +14

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

Andrew D. Wells, Li X, Yongsheng Li et al. · Nature Medicine · 1999 · 604 citations

, , +14

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

Akira Suzuki, Manae Tsukio Yamaguchi, Toshiaki Ohteki et al. · Immunity · 2001 · 589 citations · Full text

, , +16

T-Cell Tolerance: Central and Peripheral

Yan Xing, Kristin A. Hogquist · Cold Spring Harbor Perspectives in Biology · 2012 · 561 citations · Full text

, , +17

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

Jelena Nedjic, Martin Aichinger, Jan Emmerich et al. · Nature · 2008 · 509 citations

, , +14

1–5 of 343

Authors

1.6K

  1. BK
    Bruno Kyewski

    German Cancer Research Center, Germany

    10 publications · 821 citations

    10

    h-index

  2. LK
    Ludger Klein

    Ludwig-Maximilians-Universität München, Germany

    10 publications · 1.4K citations

    10

    h-index

  3. EM
    Eric Meffre

    Yale University, United States

    9 publications · 742 citations

    9

    h-index

  4. CB
    Christophe Benoıst

    Harvard University, United States

    7 publications · 1K citations

    7

    h-index

  5. DN
    David Nemazee

    Scripps Research Institute, United States

    6 publications · 378 citations

    6

    h-index

1–5 of 1.6K

Institutions

473

  1. Harvard University

    Cambridge, United States

    18 h-index

    91 publications

    10.8K citations

  2. Yale University

    New Haven, United States

    14 h-index

    87 publications

    7.2K citations

  3. National Institutes of Health

    Bethesda, United States

    13 h-index

    35 publications

    1.8K citations

  4. Brigham and Women's Hospital

    Boston, United States

    13 h-index

    49 publications

    6.5K citations

  5. German Cancer Research Center

    Heidelberg, Germany

    12 h-index

    29 publications

    2.7K citations

  6. Heidelberg University

    Heidelberg, Germany

    10 h-index

    23 publications

    2.4K citations

  7. Scripps Research Institute

    San Diego, United States

    10 h-index

    38 publications

    2.3K citations

  8. University of Minnesota

    Minneapolis, United States

    9 h-index

    25 publications

    2.1K citations

1–8 of 473

Venues

  1. The Journal of Immunology

    JI · 57 publications · 3.1K citations

    32

    h-index

  2. The Journal of Experimental Medicine

    29 publications · 3.6K citations

    23

    h-index

  3. PubMed

    Repository · 24 publications · 935 citations

    16

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 1.1K citations

    15

    h-index

  5. European Journal of Immunology

    EJI · 16 publications · 576 citations

    14

    h-index

1–5