Concepedia

Clonal Deletion

Clonal Deletion is a central tolerance mechanism in immunology whereby self-reactive T and B lymphocyte clones are selectively eliminated during development in the thymus or bone marrow through apoptosis, preventing autoimmunity.

668

Publications

49.7K

Citations

3.1K

Authors

763

Institutions

Publications per year

2017–2026

47

Parents

Publications

668

Induction by Antigen of Intrathymic Apoptosis of CD4 <sup>+</sup> CD8 <sup>+</sup> TCR <sup>lo</sup> Thymocytes in Vivo

Kenneth M. Murphy, Amy B. Heimberger, Dennis Y. Loh · Science · 1990 · 1.7K citations

, , +17

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

Janice White, Andrew Herman, Ann M. Pullen et al. · Cell · 1989 · 1.1K citations

, , +17

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

David Nemazee, Kurt Bürki · Nature · 1989 · 1K citations

, , +13

Natural History of Paroxysmal Nocturnal Hemoglobinuria

Peter Hillmen, S. M. Lewis, Monica Bessler et al. · New England Journal of Medicine · 1995 · 901 citations · Full text

, , +14

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

Charles G. Mullighan, Letha A. Phillips, Xiaoping Su et al. · Science · 2008 · 810 citations · Full text

, , +16

1–5 of 668

Authors

3.1K

  1. MS
    Megan Sykes

    Massachusetts General Hospital, United States

    11 publications · 1.3K citations

    11

    h-index

  2. HR
    H. Robson MacDonald

    Ludwig Cancer Research, Switzerland

    11 publications · 885 citations

    11

    h-index

  3. DM
    Diane Mathis

    Harvard University, United States

    10 publications · 965 citations

    10

    h-index

  4. CB
    Christophe Benoıst

    Harvard University, United States

    10 publications · 905 citations

    10

    h-index

  5. PM
    Philippa Marrack

    University of Colorado Denver, United States

    8 publications · 1.6K citations

    8

    h-index

1–5 of 3.1K

Institutions

763

  1. National Institutes of Health

    Bethesda, United States

    26 h-index

    131 publications

    9.9K citations

  2. National Cancer Institute

    Bethesda, United States

    21 h-index

    100 publications

    7.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    21 h-index

    86 publications

    17.8K citations

  4. Harvard University

    Cambridge, United States

    20 h-index

    98 publications

    9.6K citations

  5. Inserm

    Paris, France

    19 h-index

    73 publications

    6.6K citations

  6. Scripps Research Institute

    San Diego, United States

    18 h-index

    82 publications

    5.7K citations

  7. University of Toronto

    Toronto, Canada

    15 h-index

    51 publications

    3.6K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    46 publications

    2K citations

1–8 of 763

Venues

  1. The Journal of Immunology

    JI · 144 publications · 8K citations

    53

    h-index

  2. The Journal of Experimental Medicine

    72 publications · 8.1K citations

    52

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 35 publications · 3.6K citations

    29

    h-index

  4. Blood

    30 publications · 2.3K citations

    24

    h-index

  5. European Journal of Immunology

    EJI · 48 publications · 1.6K citations

    24

    h-index

1–5