Concepedia

Central Tolerance Breakdown

Central Tolerance Breakdown is a pathological immunological phenomenon characterized by the failure of central tolerance mechanisms in the thymus to eliminate self-reactive T cells, resulting in the escape of autoreactive lymphocytes that can initiate autoimmune responses.

19

Publications

1.6K

Citations

131

Authors

47

Institutions

Publications per year

2017–2026

5

Parents

Publications

19

Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells

Jacques M. Chiller, Gail S. Habicht, William O. Weigle · Science · 1971 · 370 citations

, , +13

A defect in central tolerance in NOD mice

Hidehiro Kishimoto, Jonathan Sprent · Nature Immunology · 2001 · 260 citations

, , +12

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

Fumiko Kajiura, Shijie Sun, Takashi Nomura et al. · The Journal of Immunology · 2004 · 205 citations · Full text

, , +17

Ablation and Regeneration of Tolerance-Inducing Medullary Thymic Epithelial Cells after Cyclosporine, Cyclophosphamide, and Dexamethasone Treatment

Anne Fletcher, Tamara E. Lowen, Samy Sakkal et al. · The Journal of Immunology · 2009 · 96 citations

, , +17

Thymectomy: Prolongation of Immunological Tolerance in the Adult Mouse

Henry N. Claman, David W. Talmage · Science · 1963 · 87 citations

, , +14

1–5 of 19

Authors

131

  1. HS
    Hamish S. Scott

    South Australia Pathology, Australia

    2 publications · 129 citations

    2

    h-index

  2. JN
    Jessica N. Lancaster

    The University of Texas at Austin, United States

    2 publications · 45 citations

    2

    h-index

  3. LI
    Lauren I. R. Ehrlich

    The University of Texas at Austin, United States

    2 publications · 45 citations

    2

    h-index

  4. GS
    Genevieve Stein-O’Brien

    Johns Hopkins University, United States

    1 publications · 77 citations

    1

    h-index

  5. ER
    Ellen R. Richie

    The University of Texas MD Anderson Cancer Center, United States

    1 publications · 27 citations

    1

    h-index

1–5 of 131

Institutions

47

  1. Université Paris Cité

    Paris, France

    2 h-index

    8 publications

    294 citations

  2. Inserm

    Paris, France

    2 h-index

    5 publications

    231 citations

  3. Institut Cochin

    Paris, France

    2 h-index

    4 publications

    210 citations

  4. The University of Texas at Austin

    Austin, United States

    2 h-index

    12 publications

    279 citations

  5. Washington University in St. Louis

    St Louis, United States

    1 h-index

    6 publications

    132 citations

  6. South Australia Pathology

    Adelaide, Australia

    1 h-index

    1 publications

    96 citations

  7. Edmond and Lily Safra Children's Hospital

    Ramat Gan, Israel

    1 h-index

    7 publications

    399 citations

  8. European Hospital

    Rome, Italy

    1 h-index

    1 publications

    21 citations

1–8 of 47

Venues

  1. The Journal of Immunology

    JI · 3 publications · 322 citations

    3

    h-index

  2. Nature Immunology

    2 publications · 344 citations

    2

    h-index

  3. Science

    2 publications · 457 citations

    2

    h-index

  4. The Journal of Experimental Medicine

    2 publications · 53 citations

    2

    h-index

  5. Journal of Neuroimmunology

    JNI · 1 publications · 45 citations

    1

    h-index

1–5