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Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

Peter C. Ray, Jane Wright, Julia Adam, Sylviane Boucharens, Darcey Black, Angus R. Brown, Ola Epemolu, Daniel A. Fletcher, Margaret Huggett, Phil Jones,

Bioorganic & Medicinal Chemistry Letters · 2010 · 19 citations · 13 references

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13

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature · 1997 · 2.9K citations

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The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity

Marc Jacobs, Koto Hayakawa, Lora Swenson et al. · Journal of Biological Chemistry · 2005 · 259 citations · Full text

, , +14

Efficacy and Safety of Fasudil in Patients With Stable Angina

Ralph Vicari, Bernard Chaitman, Deborah Keefe et al. · Journal of the American College of Cardiology · 2005 · 200 citations

, , +10

Protein Kinase A in Complex with Rho-Kinase Inhibitors Y-27632, Fasudil, and H-1152P

C.B. Breitenlechner, M. Gaßel, Hiroyoshi Hidaka et al. · Structure · 2003 · 158 citations · Full text

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Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors

Krista Goodman, Haifeng Cui, Sarah E. Dowdell et al. · Journal of Medicinal Chemistry · 2006 · 156 citations · Full text

, , +17