Glucuronidation of 7-Ethyl-10-hydroxycamptothecin (SN-38) by the Human UDP-Glucuronosyltransferases Encoded at the UGT1 Locus

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

Medicine, Oncology, Pharmacology +13

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

Lalitha Iyer, Christopher D. King, P. F. Whitington et al. · Journal of Clinical Investigation · 1998 · 680 citations · Full text

Medicine, Oncology, Pharmacology +17

Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats.

Kiyoshi Takasuna, Takehiro Hagiwara, Masaaki Hirohashi et al. · PubMed · 1996 · 338 citations

Medicine, Pharmacology, Toxicology +17

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

Joseph K. Ritter, John M. Crawford, I S Owens · Journal of Biological Chemistry · 1991 · 265 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications

Marco Ciotti, Aldo Marrone, Christine Potter et al. · Pharmacogenetics · 1997 · 192 citations

Life Sciences, Genetics, Molecular Biology +12