Lalitha Iyer

Genetic Variants in the <i>UDP-glucuronosyltransferase 1A1</i> Gene Predict the Risk of Severe Neutropenia of Irinotecan

Federico Innocenti, Samir D. Undevia, Lalitha Iyer et al. · Journal of Clinical Oncology · 2004 · 954 citations · Full text

Medicine, Oncology, Pharmacology +17

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

Lalitha Iyer, Soma Das, Linda Janisch et al. · The Pharmacogenomics Journal · 2002 · 712 citations

Pharmacy, Pharmacokinetics, Pharmacology +9

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

Lalitha Iyer, Christopher D. King, P. F. Whitington et al. · Journal of Clinical Investigation · 1998 · 680 citations · Full text

Medicine, Oncology, Pharmacology +17

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Margaret A. Phillips, Julie Lotharius, Kennan C. Marsh et al. · Science Translational Medicine · 2015 · 375 citations

Medicine, Pharmacology, Pharmacotherapy +9

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

Lalitha Iyer, Diana Hall, Sudip Das et al. · Clinical Pharmacology & Therapeutics · 1999 · 353 citations

Veterinary Medicine, Genetics, Molecular Genetics +15