Concepedia

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

Lalitha Iyer, Diana Hall, Sudip Das, M.P. Mortell, Jorge H Ramírez, S KIM, Mark J. Ratain

Clinical Pharmacology & Therapeutics · 1999 · 351 citations · 30 references

DOI

Abstract

The results indicate a significant association of UGT1A1 phenotype and genotype based on in vitro phenotypic measurements. The clinical significance of our finding remains to be established.

References

30

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