Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism - Concepedia

Concepedia

Publication | Closed Access

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

351

Citations

30

References

1999

Year

Lalitha Iyer, Diana Hall, Sudip Das, M.P. Mortell, Jorge H Ramírez, S KIM, Mark J. Ratain

Clinical Pharmacology & Therapeutics

Abstract

The results indicate a significant association of UGT1A1 phenotype and genotype based on in vitro phenotypic measurements. The clinical significance of our finding remains to be established.

References

	Year	Citations
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding Mark A. Bradford Analytical Biochemistry Protein ChemistryBiochemistryProtein FoldingMicrogram QuantitiesBioanalysis	1976	225.3K
The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome Piter J. Bosma, Jayanta Roy Chowdhury, Conny Bakker, New England Journal of Medicine	1995	1.5K
Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome Gemma Monaghan, Máirín Ryan, Robert Hume, The Lancet Allelic VariantGenetic DisorderGeneticsInherited Metabolic DiseaseHuman Polymorphism	1996	588
Congenital familial nonhemolytic jaundice with kernicterus. John F. Crigler, Victor A. Najjar PubMed GastroenterologyPathologyCholangiopathiesBile ThrombiSurgical Pathology	1952	551
Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. E Gupta, Timothy M. Lestingi, Rosemarie Mick, PubMed Metabolic FateGastrointestinal PharmacologyGastroenterologyPathologyPharmacotherapy	1994	506
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. Piter J. Bosma, Jurgen Seppen, Bart Goldhoorn, Journal of Biological Chemistry	1994	446
Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports Ernesto Wasserman, Anne Myara, François Lokiec, Annals of Oncology MedicineSevere Cpt-11 ToxicityCase Reports	1997	213
Sequence of Exons and the Flanking Regions of Human Bilirubin–Udp–Glucuronosyltransferase Gene Complex and Identification of A Genetic Mutation in A Patient With Crigler–Najjar Syndrome, Type I Piter J. Bosma, Namita Roy Chowdhury, Bart Goldhoorn, Hepatology	1992	201
Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome S. Aono, Hiroomi Keino, Yasukazu Yamada, The Lancet Mendelian DisorderGenetic DisorderGeneticsInherited Metabolic DiseaseBilirubin Udp-glucuronosyltransferase	1995	193
Population studies on Gilbert's syndrome. D. Owens, James Evans Journal of Medical Genetics UrologyHematologyPediatricsPopulation StudiesBimodal Distribution	1975	190

Page 1