Concepedia

Glucuronidation Pathways

Glucuronidation Pathways is a biochemical detoxification mechanism in carcinogen metabolism that involves the conjugation of glucuronic acid to xenobiotics or their metabolites via UDP-glucuronosyltransferase enzymes, thereby enhancing their water solubility and facilitating biliary or renal excretion.

2.2K

Publications

103.7K

Citations

6.5K

Authors

1.3K

Institutions

Publications per year

2017–2026

173

Parents

Publications

2.2K

Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers

Guido Shoba, David C. Joy, Thangam Joseph et al. · Planta Medica · 1998 · 1.9K citations

, , +13

Biotransformation of Curcumin Through Reduction and Glucuronidation in Mice

Min‐Hsiung Pan, Tsang‐Miao Huang, Jen‐Kun Lin · Drug Metabolism and Disposition · 1999 · 943 citations

, , +8

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

Lalitha Iyer, Christopher D. King, P. F. Whitington et al. · Journal of Clinical Investigation · 1998 · 680 citations · Full text

, , +17

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.

E Gupta, Timothy M. Lestingi, Rosemarie Mick et al. · PubMed · 1994 · 506 citations

, , +14

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

Piter J. Bosma, Jurgen Seppen, Bart Goldhoorn et al. · Journal of Biological Chemistry · 1994 · 449 citations · Full text

, , +11

1–5 of 2.2K

Authors

6.5K

  1. BB
    Brian Burchell

    University of Dundee, United Kingdom

    72 publications · 4K citations

    38

    h-index

  2. JO
    John O. Miners

    Flinders Medical Centre, Australia

    41 publications · 3.5K citations

    34

    h-index

  3. PI
    Peter I. Mackenzie

    Flinders University, Australia

    49 publications · 3.8K citations

    34

    h-index

  4. MF
    Moshe Finel

    University of Helsinki, Finland

    50 publications · 2.4K citations

    31

    h-index

  5. KW
    Karl Walter Bock

    University of Tübingen, Germany

    42 publications · 2.3K citations

    29

    h-index

1–5 of 6.5K

Institutions

1.3K

  1. Flinders University

    Adelaide, Australia

    32 h-index

    132 publications

    8.3K citations

  2. Université Laval

    Québec, Canada

    32 h-index

    292 publications

    18.7K citations

  3. University of Helsinki

    Helsinki, Finland

    32 h-index

    189 publications

    10.6K citations

  4. Flinders Medical Centre

    Bedford Park, Australia

    31 h-index

    108 publications

    8.3K citations

  5. University of Dundee

    Dundee, United Kingdom

    28 h-index

    118 publications

    5.9K citations

  6. University of Iowa

    Iowa City, United States

    27 h-index

    73 publications

    9K citations

  7. University of California San Diego

    San Diego, United States

    26 h-index

    103 publications

    7.8K citations

  8. Ninewells Hospital

    Dundee, United Kingdom

    25 h-index

    100 publications

    4.7K citations

1–8 of 1.3K

Venues

  1. Drug Metabolism and Disposition

    333 publications · 20.2K citations

    77

    h-index

  2. Biochemical Pharmacology

    156 publications · 6.3K citations

    45

    h-index

  3. PubMed

    Repository · 102 publications · 6.3K citations

    43

    h-index

  4. Journal of Biological Chemistry

    JBC · 49 publications · 4.2K citations

    34

    h-index

  5. 31

    h-index

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