Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.

E Gupta, Timothy M. Lestingi, Rosemarie Mick, +2

PubMed

Metabolic FateGastrointestinal PharmacologyGastroenterologyPathologyPharmacotherapy +19

Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients.

E Gupta, Rosemarie Mick, Xiaolin Wang, +3

Journal of Clinical Oncology

Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital

E Gupta, Xiaolin Wang, Jacqueline Ramı́rez, +1

Cancer Chemotherapy and Pharmacology

BiosynthesisValproic AcidBiochemistryMedicineNutraceutical Ingredient +7

Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A.

E Gupta, Ahmad R. Safa, Xiaolin Wang, +1

PubMed

HepatologyBiliary TractMedicinePhysiologyCyclosporin A +10

Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: prediction of biliary index and intestinal toxicity.

Rosemarie Mick, E Gupta, Everett E. Vokes, +1

Journal of Clinical Oncology

Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent.

E Gupta, Olufunmilayo I. Olopade, Mark J. Ratain, +5

PubMed

Chemopreventive AgentAllergyPharmacological StudyDrug DiscoveryOltipraz Cmax +9

Phase I Clinical and Pharmacologic Study of 13-<i>cis</i>-Retinoic Acid, Interferon Alfa, and Paclitaxel in Patients With Prostate Cancer and Other Advanced Malignancies

Robert S. DiPaola, Mohamed M. Rafi, Viral Vyas, +11

Journal of Clinical Oncology

Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.

Ahamed Saleem, Nageatte Ibrahim, Manisha Patel, +5

PubMed

Chemoprevention StrategyTumor BiologyToxicological MechanismOxidative StressDrug Resistance +16

The intestinal absorption of camptothecin, a highly lipophilic drug, across Caco-2 cells is mediated by active transporter(s).

E Gupta, Feijun Luo, Alice Lallo, +4

PubMed

Gastrointestinal PharmacologyGastroenterologyCellular PharmacologyDigestive TractCpt Transport +18

Similarity-based parameter transferability in the quantum approximate optimization algorithm

Alexey Galda, E Gupta, Jose Falla, +4

Frontiers in Quantum Science and Technology

EngineeringQuantum ComputingQuantum Optimization AlgorithmSimilarity-based Parameter TransferabilityOptimal Qaoa Parameters +15