Masaaki Hirohashi

Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats.

Kiyoshi Takasuna, Takehiro Hagiwara, Masaaki Hirohashi et al. · PubMed · 1996 · 338 citations

Biochemistry, Gastrointestinal Pharmacology, Intestinal Microflora +14

Inhibition of intestinal microflora β-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats

Kiyoshi Takasuna, Takehiro Hagiwara, Masaaki Hirohashi et al. · Cancer Chemotherapy and Pharmacology · 1998 · 115 citations

Gastrointestinal Pharmacology, Medicine, Gastroenterology +7

Protective Effects of <i>Kampo</i> Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT‐11), in Rats

Kiyoshi Takasuna, Yoshio Kasai, Yutaka Kitano et al. · Japanese Journal of Cancer Research · 1995 · 97 citations · Full text

Increasing-current electroshock seizure test: A new method for assessment of anti- and pro-convulsant activities of drugs in mice

Yutaka Kitano, Chiharu Usui, Kiyoshi Takasuna et al. · Journal of Pharmacological and Toxicological Methods · 1996 · 66 citations

Neurophysiology, Medicine, Pharmacology +13

Enhancement of immobility in mouse forced swimming test by treatment with human interferon

Mitsuhiro Makino, Yutaka Kitano, Masaaki Hirohashi et al. · European Journal of Pharmacology · 1998 · 51 citations

Knockout Mouse, Human Interferon, Immunology +1