Therapeutic strategies for targeting PTP1B in diabetes

Insulin signalling and the regulation of glucose and lipid metabolism

Alan R. Saltiel, C. Ronald Kahn · Nature · 2001 · 5.3K citations · Full text

Life Sciences, Biochemistry, Endocrinology +14

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Lori D. Klaman, Olivier Boss, Odile D. Peroni et al. · Molecular and Cellular Biology · 2000 · 1.2K citations

Life Sciences, Endocrinology, Molecular Biology +17

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

Seung-Rock Lee, Ki‐Sun Kwon, Seung-Ryul Kim et al. · Journal of Biological Chemistry · 1998 · 974 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

David Barford, Andrew Flint, Nicholas K. Tonks · Science · 1994 · 759 citations

Life Sciences, Biochemistry, Molecular Biology +17

Allosteric inhibition of protein tyrosine phosphatase 1B

Christian Wiesmann, Kenneth J. Barr, Jenny Kung et al. · Nature Structural & Molecular Biology · 2004 · 530 citations

Life Sciences, Biochemistry, Molecular Biology +14