Concepedia

Receptor-mediated Targeting

Receptor-Mediated Targeting is an active targeted drug delivery strategy that exploits specific interactions between ligands on a therapeutic agent or carrier and cell-surface receptors, typically overexpressed on diseased cells relative to normal tissue, to achieve selective binding, internalization, and accumulation of the drug at the intended site of action.

747

Publications

50.6K

Citations

4.8K

Authors

1.1K

Institutions

Publications per year

2017–2026

267

Parents

Children

Publications

747

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

Wadih Arap, Renata Pasqualini, Erkki Ruoslahti · Science · 1998 · 2.1K citations

, , +17

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

Laura A. Johnson, Richard A. Morgan, Mark E. Dudley et al. · Blood · 2009 · 1.4K citations · Full text

, , +17

Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules

Makoto Mitsunaga, Mikako Ogawa, Nobuyuki Kosaka et al. · Nature Medicine · 2011 · 1K citations

, , +16

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

Erwei Song, Pengcheng Zhu, Sang‐Kyung Lee et al. · Nature Biotechnology · 2005 · 1K citations

, , +14

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

Irfan A. Asangani, Vijaya L. Dommeti, Xiaoju Wang et al. · Nature · 2014 · 952 citations · Full text

, , +16

1–5 of 747

Authors

4.8K

  1. PS
    Philip S. Low

    Purdue University West Lafayette, United States

    16 publications · 2K citations

    15

    h-index

  2. DT
    David T. Curiel

    University of Alabama at Birmingham, United States

    13 publications · 892 citations

    12

    h-index

  3. RP
    Renata Pasqualini

    The University of Texas MD Anderson Cancer Center, United States

    9 publications · 2.8K citations

    9

    h-index

  4. TJ
    Thomas J. Wickham

    GenVec, United States

    8 publications · 1.2K citations

    8

    h-index

  5. EW
    Ernst Wagner

    Ludwig-Maximilians-Universität München, Germany

    7 publications · 199 citations

    7

    h-index

1–5 of 4.8K

Institutions

1.1K

  1. Harvard University

    Cambridge, United States

    19 h-index

    79 publications

    16.2K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    70 publications

    2.5K citations

  3. Purdue University West Lafayette

    West Lafayette, United States

    14 h-index

    49 publications

    4.8K citations

  4. University of Alabama at Birmingham

    Birmingham, United States

    14 h-index

    61 publications

    3.3K citations

  5. National Cancer Institute

    Bethesda, United States

    12 h-index

    75 publications

    37.9K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    12 h-index

    43 publications

    5.5K citations

  7. Center for Cancer Research

    Bethesda, United States

    11 h-index

    43 publications

    10.7K citations

  8. Fudan University

    Shanghai, China

    11 h-index

    64 publications

    3.7K citations

1–8 of 1.1K

Venues

  1. Journal of Controlled Release

    26 publications · 2.5K citations

    21

    h-index

  2. Bioconjugate Chemistry

    22 publications · 2K citations

    20

    h-index

  3. PubMed

    Repository · 24 publications · 1.5K citations

    19

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 1.4K citations

    16

    h-index

  5. Biomaterials

    15 publications · 657 citations

    15

    h-index

1–5