Concepedia

Design and synthesis of tricyclic cores for kinase inhibition

Stacy Van Epps, Bryan A. Fiamengo, Jeremy J. Edmunds, Anna Ericsson, Kristine E. Frank, Michael Friedman, Dawn M. George, Jonathan H. George, Eric R. Goedken, Brian Kotecki,

Bioorganic & Medicinal Chemistry Letters · 2012 · 22 citations · 7 references

DOIFull text

Open access

Concepts

References

7

An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three‐month randomized, placebo‐controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents

Mark C. Genovese, Arthur Kavanaugh, Michael E. Weinblatt et al. · Arthritis & Rheumatism · 2010 · 209 citations

, , +17

[(CyPF-<sup><i>t</i></sup>Bu)PdCl<sub>2</sub>]: An Air-Stable, One-Component, Highly Efficient Catalyst for Amination of Heteroaryl and Aryl Halides

Qilong Shen, John F. Hartwig · Organic Letters · 2008 · 137 citations · Full text

, , +15

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Janusz J. Kulagowski, Wade Blair, Richard J. Bull et al. · Journal of Medicinal Chemistry · 2012 · 94 citations · Full text

, , +15

Discovery and Optimization of <i>C</i>-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Mark Zak, Rohan Mendonca, Mercedesz Balázs et al. · Journal of Medicinal Chemistry · 2012 · 61 citations · Full text

, , +16

Synthesis of functionalized 7-azaindoles via directed ortho-metalations

Alexandre L’Heureux, Carl Thibault, Réjean Ruel · Tetrahedron Letters · 2004 · 27 citations

, , +12