Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors

Margarita García‐Calvo, Erin P. Peterson, Barbara Leiting, +3

Journal of Biological Chemistry

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

Mark Abramovitz, Mohammed Adam, Yves Boie, +16

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Related AnalogsSignal TransductionBiochemistryFunctional SelectivityMedicine +11

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

Iman Fares, Jalila Chagraoui, Yves Gareau, +19

Science

Cell TherapyImmunologyBlood CellStem Cell MobilizationStem Cell Transplantation +16

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

J. Rotonda, Donald W. Nicholson, Kimberly M. Fazil, +9

Nature Structural Biology

Protein FunctionSignal TransductionBiochemistryOrganelle DynamicNatural Sciences +10

Identification of small molecules that support human leukemia stem cell activity ex vivo

Caroline Pabst, Jana Krošl, Iman Fares, +6

Nature Methods

Hematological MalignancyMedicineNatural SciencesSmall MoleculesMixed-phenotype Acute Leukemia +7

Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis

Laurent Frédéric Gil, Yongxin Han, Evan E. Opas, +5

Bioorganic & Medicinal Chemistry

Bone DiseaseSclerostinMedicineOsteoarthritisPharmacotherapy +4

Conformationally Constrained <i>ortho-</i>Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y₁ Antagonist

Jennifer X. Qiao, Tammy C. Wang, Réjean Ruel, +25

Journal of Medicinal Chemistry

ThrombosisMedicinal ChemistryBiochemistryMedicineNatural Sciences +11

Single-Step Preparation of 1-Hydroxybisphosphonates via Addition of Dialkyl Phosphite Potassium Anions to Acid Chlorides

Réjean Ruel, Jean‐Pierre Bouvier, Robert N. Young

The Journal of Organic Chemistry

Inorganic ChemistryChemical EngineeringChemical MeasurementEngineeringChemical Analysis +11

Stereoselective synthesis of <i>cis</i>-decalins via Diels–Alder and double Michael addition of substituted Nazarov reagents

Jean-François Lavallée, Claude Spino, Réjean Ruel, +2

Canadian Journal of Chemistry

Double Michael Cyclization1-Phenylsulfinyl AnalogsEngineeringDouble Michael AdditionOrganic Chemistry +7

Convenient access to two enantiomeric oxirane synthons bearing a quaternary gem-dimethyl carbon center: Synthesis of 3S-(+) and 3R-(−)-2,2-dimethyl-3,4-oxo-1-butanol from R-(−)-pantolactone

Pierre Lavallée, Réjean Ruel, Louis Grenier, +1

Tetrahedron Letters

EngineeringConvenient AccessOrganic ChemistryStereoselective SynthesisChemistry +5