Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry, +13

Nature

Protein FunctionBiochemistryIce/ced-3 ProteaseMedicineApoptosis +9

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

Mark Abramovitz, Mohammed Adam, Yves Boie, +16

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Related AnalogsSignal TransductionBiochemistryFunctional SelectivityMedicine +11

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

Iman Fares, Jalila Chagraoui, Yves Gareau, +19

Science

Cell TherapyImmunologyBlood CellStem Cell MobilizationStem Cell Transplantation +16

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

J. Rotonda, Donald W. Nicholson, Kimberly M. Fazil, +9

Nature Structural Biology

Protein FunctionSignal TransductionBiochemistryOrganelle DynamicNatural Sciences +10

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

Irène Baccelli, Yves Gareau, Bernhard Lehnertz, +26

Cancer Cell

Hematological MalignancyBiochemistryNatural SciencesAcute Myeloid LeukemiaOxphos Dependency +7

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.

Deborah Slipetz, Gary P. O’Neill, Leonard Favreau, +6

Molecular Pharmacology

Maintenance of caspase-3 proenzyme dormancy by an intrinsic “safety catch” regulatory tripeptide

Sophie Roy, Christopher I. Bayly, Yves Gareau, +7

Proceedings of the National Academy of Sciences

Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

Denis Riendeau, Renée Aspiotis, Diane Ethier, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +3

Structure–activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor

Hélène Jûteau, Yves Gareau, Marc Labelle, +7

Bioorganic & Medicinal Chemistry

Structure–activity RelationshipMolecular PharmacologyBiochemistryMedicineMechanism Of Action +5

Structure activity relationships of tetrahydrocannabinol analogues on human cannabinoid receptors

Yves Gareau, Claude Dufresne, Michel Gallant, +7

Bioorganic & Medicinal Chemistry Letters

Cannabis UseBiochemistryG Protein-coupled ReceptorNatural SciencesMedicine +8