Dawn M. George

Discovery of Selective and Orally Bioavailable Protein Kinase Cθ (PKCθ) Inhibitors from a Fragment Hit

Dawn M. George, Eric C. Breinlinger, Michael Friedman et al. · Journal of Medicinal Chemistry · 2014 · 42 citations · Full text

Drug Target, Immunology, Pharmacotherapy +19

Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3

Martin E. Hayes, Grier A. Wallace, Pintipa Grongsaard et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 38 citations · Full text

Drug Target, Chemokine Receptor Cxcr3, Biochemistry +9

Optimized Protein Kinase Cθ (PKCθ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis

Dawn M. George, Eric C. Breinlinger, M.A. Argiriadi et al. · Journal of Medicinal Chemistry · 2014 · 30 citations · Full text

Immunology, Rodent Model, Cellular Pharmacology +27

Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-α production

Kevin P. Cusack, Hamish Allen, Agnieszka K. Bischoff et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 27 citations · Full text

Cot Kinase, Molecular Pharmacology, Medicinal Chemistry +7

Discovery of thieno[2,3-c]pyridines as potent COT inhibitors

Dawn M. George, Michael Friedman, Hamish Allen et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 25 citations · Full text

Medicinal Chemistry, Medicine, Natural Sciences +7