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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee, Joo‐Ho Shin, Jackalina VanKampen, Leonard Petrucelli, Andrew B. West, Han Seok Ko, Yun-Il Lee, Kathleen A. Maguire‐Zeiss, William J. Bowers, Howard J. Federoff,

Nature Medicine · 2010 · 382 citations · 12 references

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12

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

Elisa Greggio, Shushant Jain, Ann E. Kingsbury et al. · Neurobiology of Disease · 2006 · 748 citations · Full text

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Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

Sophie Leclerc, Matthieu Garnier, Ralph Hoessel et al. · Journal of Biological Chemistry · 2001 · 723 citations · Full text

, , +13

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Wanli W. Smith, Zhong Pei, Haibing Jiang et al. · Nature Neuroscience · 2006 · 623 citations

, , +16

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Andrew B. West, Darren J. Moore, Catherine Choi et al. · Human Molecular Genetics · 2007 · 606 citations

, , +17

Phosphorylation of 4E‐BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

Yuzuru Imai, Stephan Gehrke, Hua-Qin Wang et al. · The EMBO Journal · 2008 · 432 citations · Full text

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