Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Coro Paisán‐Ruíz, Shushant Jain, E. Whitney Evans, +17

Neuron

Neurodegenerative DiseasesGenetic DisorderParkinson DiseaseGeneticsGene Containing Mutations +7

A common LRRK2 mutation in idiopathic Parkinson's disease

William P. Gilks, Patrick M. Abou‐Sleiman, Sonia Gandhi, +12

The Lancet

Mendelian DisorderParkinson DiseasePathologyDisease Gene IdentificationMedicine +1

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

Elisa Greggio, Shushant Jain, Ann E. Kingsbury, +14

Neurobiology of Disease

Mutant Lrrk2/dardarinSignal TransductionSignaling PathwayMolecular PathwayMedicine +9

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

William C. Nichols, Nathan Pankratz, Dena Hernández, +9

The Lancet

Mendelian DisorderFamilial ParkinsonGenetic DisorderParkinson DiseaseGenetics +5

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

Naheed L. Khan, Shushant Jain, John Lynch, +24

Brain

Motor DysfunctionNeurological DisorderCorticobasal DegenerationGeneticsPathology +20

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

Elisa Greggio, Ibardo Zambrano, Alice Kaganovich, +10

Journal of Biological Chemistry

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Patrick A. Lewis, Elisa Greggio, Alexandra Beilina, +3

Biochemical and Biophysical Research Communications

R1441c MutationBiochemical GeneticsBiochemistryProtein Phosphorylation

Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing

Iris E. Jansen, Hui Ye, Sasja Heetveld, +29

Genome biology

Clinical and positron emission tomography of Parkinson's disease caused by <i>LRRK2</i>

Dena Hernández, Coro Paisán‐Ruíz, Aideen McInerney‐Leo, +10

Annals of Neurology

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

Christian Haenig, Nir Atias, Alexander K. Taylor, +22

Cell Reports