Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

Wei Zhang, Tongguang Wang, Zhong Pei, +8

The FASEB Journal

Neurodegenerative DiseasesResident MicrogliaNadph OxidaseMedicineInflammatory Process +12

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Wanli W. Smith, Zhong Pei, Haibing Jiang, +3

Nature Neuroscience

Signal TransductionMolecular NeuroscienceCell DeathKinase ActivityNeuroprotection +4

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

Wanli W. Smith, Zhong Pei, Haibing Jiang, +6

Proceedings of the National Academy of Sciences

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

Wanli W. Smith, Haibing Jiang, Zhong Pei, +6

Human Molecular Genetics

A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease

Sen Yan, Zhuchi Tu, Zhaoming Liu, +18

Cell

Knockout MouseNeurodegenerative DiseasesNeurobiology Of DiseaseHuntington ’Genetics +11

AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research

Haibin Liu, Lirong Wang, Mingliang Lv, +6

Journal of Chemical Information and Modeling

Drug TargetEngineeringNeurogenomicsMolecular BiologyNeurochemical Biomarkers +16

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Lei Han, Xiaoyu Wei, Chuanyu Liu, +74

Nature

Human CellFunctional GenomicsSequence AnalysisGene StructureCell Transcriptomic Atlas +4

High-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Functional Recovery by Enhancing Neurogenesis and Activating BDNF/TrkB Signaling in Ischemic Rats

Jing Luo, Haiqing Zheng, Liying Zhang, +4

International Journal of Molecular Sciences

High-frequency Rtms MethodsHigh-frequency RtmsSocial SciencesCerebral Vascular RegulationNeuroinflammation +23

Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction

Shihui Xing, Yusheng Zhang, Jingjing Li, +8

Autophagy

Cell DeathNeurochemical BiomarkersSecondary DamageSocial SciencesCerebral Vascular Regulation +22

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

Haibing Jiang, Michelle A. Poirier, Yideng Liang, +5

Neurobiology of Disease

Cellular ToxicityImmunologyCell DeathToxicologyMutagenesis +6