A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease

Sen Yan, Zhuchi Tu, Zhaoming Liu, +18

Cell

Knockout MouseNeurodegenerative DiseasesNeurobiology Of DiseaseHuntington ’Genetics +11

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

Yongchang Chen, Yinghui Zheng, Yu Kang, +12

Human Molecular Genetics

Dystrophin GeneEngineeringGeneticsMolecular GeneticsEarly Dmd +14

Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

Zhuchi Tu, Weili Yang, Sen Yan, +10

Scientific Reports

Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates

Hui Zhao, Qiqi Wang, Ting Yan, +9

Translational Psychiatry

Autism-like BehaviorsNeurodiversityAutismNeurologyNeuroimmunology +16

Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain

Weili Yang, Guohao Wang, Chuan-En Wang, +9

Journal of Neuroscience

CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms

Zhuchi Tu, Hui Zhao, Bang Li, +14

Human Molecular Genetics

ImmunologyMolecular BiologyDrug-treatable Autism-like SymptomsAutism Spectrum DisorderMonkey Leads +16

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis

Weili Yang, Xiangyu Guo, Zhuchi Tu, +18

Protein & Cell

Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease

Sen Yan, Xiaoming Zheng, Yingqi Lin, +15

Nature Biomedical Engineering

Cas9-mediated ReplacementGenome InstabilityNeurodegenerative DiseasesPig ModelGenetic Disorder +7

Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin

Peng Yin, Zhuchi Tu, Yin An, +11

Human Molecular Genetics

Neurodegenerative DiseasesDevelopmental BiologyAlzheimer's DiseaseMolecular NeuroscienceMutant Huntingtin +13

Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Yingqi Lin, Caijuan Li, Wei Wang, +14

Frontiers in Cell and Developmental Biology

Widespread DistributionTranslational MedicineNeurodegenerative DiseasesMedicineNeurovirology +12