Discovery and preliminary evaluation of 2-aminobenzamide and hydroxamate derivatives containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors

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Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

Life Sciences, Genetics, Molecular Biology +16

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

John R. Somoza, R.J. Skene, B.A. Katz et al. · Structure · 2004 · 698 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked <i>in vivo</i> antitumor activity against human tumors

Akiko Saito, Takashi Yamashita, Yukiyasu Mariko et al. · Proceedings of the National Academy of Sciences · 1999 · 696 citations · Full text

Medicine, Oncology, Pharmacology +13

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Benjamin Lauffer, Robert Mintzer, Rina Fong et al. · Journal of Biological Chemistry · 2013 · 412 citations · Full text

Medicine, Oncology, Pharmacology +15

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou et al. · Molecular Cancer Therapeutics · 2008 · 336 citations · Full text

Medicine, Oncology, Pharmacology +13