MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou, +17

Molecular Cancer Therapeutics

Tumor BiologyInhibitory ActivityMedicineHdac IsotypePharmacology +11

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

Lionel M.L. Chow, Marielle Fournel, Dominique Davidson, +1

Nature

Signal TransductionSignaling PathwayReceptor Tyrosine KinaseT-regulatory CellImmunology +6

Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity

Oscar Moradei, Tammy C. Mallais, Sylvie Fréchette, +14

Journal of Medicinal Chemistry

Inhibitory ActivityMedicinal ChemistryBioorganic ChemistryBiochemistryUnusual Bis +13

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

Dominique Davidson, Lionel M.L. Chow, Marielle Fournel, +1

The Journal of Experimental Medicine

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismAntigen Processing +14

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.

Marielle Fournel, Dominique Davidson, Robert Weil, +1

The Journal of Experimental Medicine

T-regulatory CellImmunologyImmune RegulationPathologyCell Death +17

Down-regulation of Human DNA-(Cytosine-5) Methyltransferase Induces Cell Cycle Regulators p16 and p21WAF/Cip1 by Distinct Mechanisms

Marielle Fournel, Przemysław Sapieha, Normand Beaulieu, +2

Journal of Biological Chemistry

Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor

Nancy Zhou, Oscar Moradei, Stéphane Raeppel, +19

Journal of Medicinal Chemistry

Compound 8Chemoprevention StrategyPharmacotherapyInduces HistoneChemical Biology +16

Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.

Marielle Fournel, Marie-Claude Trachy-Bourget, Ann Kalita, +10

PubMed

Histone DeacetylasesChemoprevention StrategyPharmacotherapyCancer BiologyPharmaceutical Chemistry +19

Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

André Veillette, Lorraine Caron, Marielle Fournel, +1

PubMed

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

David Smil, Sukhdev Manku, Yves Chantigny, +13

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyChromatinBiochemistryMedicineNatural Sciences +4