Oscar Moradei

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou et al. · Molecular Cancer Therapeutics · 2008 · 333 citations · Full text

Tumor Biology, Inhibitory Activity, Medicine +13

Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity

Oscar Moradei, Tammy C. Mallais, Sylvie Fréchette et al. · Journal of Medicinal Chemistry · 2007 · 161 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Bioorganic Chemistry +15

Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound

Lorna H. Mitchell, Allison E. Drew, Scott Ribich et al. · ACS Medicinal Chemistry Letters · 2015 · 134 citations · Full text

Drug Target, Pharmacotherapy, Chemical Biology +18

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

Allison E. Drew, Oscar Moradei, Suzanne L. Jacques et al. · Scientific Reports · 2017 · 131 citations · Full text

Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor

Nancy Zhou, Oscar Moradei, Stéphane Raeppel et al. · Journal of Medicinal Chemistry · 2008 · 108 citations · Full text

Compound 8, Chemoprevention Strategy, Pharmacotherapy +18