PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells

Adrienne Boire, Lidija Covic, Anika Agarwal, +3

Cell

Breast OncologyMedicineBreast Cancer CellsMatrix Metalloprotease-1 ReceptorCell-matrix Interaction +7

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre, Kristy G. Kuplast, Christina R. Majer, +27

Nature Chemical Biology

Vitro PotencySignal TransductionMedicineMcl ModelsSelective Inhibitor +8

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

K.S. Gajiwala, Joe C. Wu, James G. Christensen, +19

Proceedings of the National Academy of Sciences

Kit Kinase MutantsCancer BiologyTumor BiologyDrug ResistanceGastrointestinal Oncology +14

Blocking the Protease-Activated Receptor 1-4 Heterodimer in Platelet-Mediated Thrombosis

Andrew J. Leger, Suzanne L. Jacques, Jehangir Badar, +5

Circulation

Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound

Lorna H. Mitchell, Allison E. Drew, Scott Ribich, +14

ACS Medicinal Chemistry Letters

Drug TargetPharmacotherapyChemical BiologyPharmaceutical ChemistryPrmt6 Overexpression +16

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

Allison E. Drew, Oscar Moradei, Suzanne L. Jacques, +21

Scientific Reports

Structure of the Catalytic Domain of Human Polo-like Kinase 1^,

Michael Kothe, Darcy Kohls, Simon Low, +12

Biochemistry

Catalytic DomainMolecular BiologyChemical BiologyTumor BiologySignaling Pathway +17

Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage

Suzanne L. Jacques, Athan Kuliopulos

Biochemical Journal

Thrombin RecognitionMolecular BiologyInitial Thrombin BindingAnionic Retention MotifThrombosis +22

Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor

Lorna H. Mitchell, P. Ann Boriack‐Sjodin, Sherri Smith, +18

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceChemoprevention StrategyCancer BiologySmyd3 InhibitorsPharmaceutical Chemistry +16

Substrate-Assisted Catalysis of the PAR1 Thrombin Receptor

Suzanne L. Jacques, Meredith LeMasurier, Paul Sheridan, +2

Journal of Biological Chemistry

Par1 ReceptorProtein FunctionSignal TransductionBiochemistryProtein Assembly +9