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Substrate Specificity of Rhomboid Intramembrane Proteases Is Governed by Helix-Breaking Residues in the Substrate Transmembrane Domain

Siniša Urban, Matthew Freeman

Molecular Cell · 2003 · 238 citations · 31 references

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31

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

, , +8

Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine Proteases

Siniša Urban, Jeffrey R. Lee, Matthew Freeman · Cell · 2001 · 568 citations · Full text

, , +9

Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease

Andreas Weihofen, Kathleen L. Binns, Marius K. Lemberg et al. · Science · 2002 · 529 citations

, , +16

Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

Robert B. Rawson, Nikolai G. Zelenski, Deepak Nijhawan et al. · Molecular Cell · 1997 · 460 citations · Full text

, , +15

Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins

Gary Struhl, Atsuko Adachi · Molecular Cell · 2000 · 427 citations · Full text

, , +12