Concepedia

Protease Substrate Specificity

Protease Substrate Specificity is the inherent biochemical property of a protease that determines the precise recognition and selective cleavage of peptide bonds within substrate proteins based on specific amino acid sequence, structural, or physicochemical features surrounding the cleavage site.

1.5K

Publications

94.4K

Citations

5.8K

Authors

1.3K

Institutions

Publications per year

2017–2026

124

Variants

Proteolytic Substrate Specificity

Parents

Publications

1.5K

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

Nancy A. Thornberry, Thomas A. Rano, Erin P. Peterson et al. · Journal of Biological Chemistry · 1997 · 2.1K citations · Full text

, , +14

Substrate Specificities of Caspase Family Proteases

Robert V. Talanian, Christopher Quinlan, Simone Trautz et al. · Journal of Biological Chemistry · 1997 · 882 citations · Full text

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Staphylococcal Protease: A Proteolytic Enzyme Specific for Glutamoyl Bonds

Jean Houmard, Gabriel R. Drapeau · Proceedings of the National Academy of Sciences · 1972 · 702 citations · Full text

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Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

David Julius, Anthony J. Brake, Lindley C. Blair et al. · Cell · 1984 · 700 citations

, , +8

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

Sean S. Molloy, Patricia A. Bresnahan, S H Leppla et al. · Journal of Biological Chemistry · 1992 · 693 citations · Full text

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1–5 of 1.5K

Authors

5.8K

  1. CS
    Charles S. Craik

    University of California, San Francisco, United States

    39 publications · 4.4K citations

    31

    h-index

  2. LJ
    Luiz Juliano

    Universidade Federal de São Paulo, Brazil

    23 publications · 1.2K citations

    18

    h-index

  3. MA
    María A. Juliano

    Universidade Federal de São Paulo, Brazil

    18 publications · 815 citations

    15

    h-index

  4. MD
    Marcin Drąg

    Wrocław University of Science and Technology, Poland

    15 publications · 928 citations

    15

    h-index

  5. GS
    Guy S. Salvesen

    Sanford Burnham Prebys Medical Discovery Institute, United States

    15 publications · 1.5K citations

    15

    h-index

1–5 of 5.8K

Institutions

1.3K

  1. University of California, San Francisco

    San Francisco, United States

    41 h-index

    211 publications

    23.3K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    32 h-index

    81 publications

    7.1K citations

  3. National Institutes of Health

    Bethesda, United States

    26 h-index

    99 publications

    7.4K citations

  4. Washington University in St. Louis

    St Louis, United States

    19 h-index

    64 publications

    4.6K citations

  5. Monash University

    Melbourne, Australia

    18 h-index

    74 publications

    6.3K citations

  6. Scripps Research Institute

    San Diego, United States

    18 h-index

    59 publications

    3.3K citations

  7. Harvard University

    Cambridge, United States

    18 h-index

    91 publications

    10.6K citations

  8. University of British Columbia

    Vancouver, Canada

    17 h-index

    72 publications

    7.2K citations

1–8 of 1.3K

Venues

  1. Journal of Biological Chemistry

    JBC · 265 publications · 25.4K citations

    84

    h-index

  2. Biochemistry

    117 publications · 6.7K citations

    50

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 57 publications · 7.8K citations

    45

    h-index

  4. European Journal of Biochemistry

    EJB · 53 publications · 2.7K citations

    30

    h-index

  5. FEBS Letters

    44 publications · 1.8K citations

    26

    h-index

1–5