Sean S. Molloy

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

Sean S. Molloy, Patricia A. Bresnahan, S H Leppla et al. · Journal of Biological Chemistry · 1992 · 690 citations · Full text

Toxin Protective Antigen, Protein Secretion, Immunology +18

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

Sean S. Molloy, Laurel Thomas, Judy K. VanSlyke et al. · The EMBO Journal · 1994 · 493 citations · Full text

Protein Secretion, Signal Transduction, Biochemistry +13

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

Kurt R. Klimpel, Sean S. Molloy, Gary Thomas et al. · Proceedings of the National Academy of Sciences · 1992 · 458 citations · Full text

PACS-1 Defines a Novel Gene Family of Cytosolic Sorting Proteins Required for trans-Golgi Network Localization

Lei Wan, Sean S. Molloy, Laurel Thomas et al. · Cell · 1998 · 378 citations · Full text

Signal Transduction, Novel Gene Family, Molecular Biology +10

Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.

B. G. Jones, Laurel Thomas, Sean S. Molloy et al. · The EMBO Journal · 1995 · 186 citations · Full text

Signal Transduction, Natural Sciences, Phosphorylation State +10