Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

Sean S. Molloy, Patricia A. Bresnahan, S H Leppla, +2

Journal of Biological Chemistry

Toxin Protective AntigenProtein SecretionImmunologyPathologyCytoskeleton +16

PACS‐2 controls endoplasmic reticulum–mitochondria communication and Bid‐mediated apoptosis

Thomas Simmen, Joseph E. Aslan, Anastassia D. Blagoveshchenskaya, +7

The EMBO Journal

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

Kurt R. Klimpel, Sean S. Molloy, Gary Thomas, +1

Proceedings of the National Academy of Sciences

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

Patricia A. Bresnahan, Richard Leduc, Laurel Thomas, +5

The Journal of Cell Biology

Protein SecretionGeneticsImmunologyMolecular GeneticsCytoskeleton +21

PACS-1 Defines a Novel Gene Family of Cytosolic Sorting Proteins Required for trans-Golgi Network Localization

Lei Wan, Sean S. Molloy, Laurel Thomas, +4

Cell

Signal TransductionNovel Gene FamilyMolecular BiologyTrans-golgi Network LocalizationMolecular Sorting +8

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

Vincent Piguet, Lei Wan, Christelle Borel, +4

Nature Cell Biology

Major Histocompatibility ComplexesCellular Protein Pacs-1Human RetrovirusImmunologyAntiviral Response +7

HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway

Anastassia D. Blagoveshchenskaya, Laurel Thomas, Sylvain Féliciangéli, +2

Cell

MedicineHuman RetrovirusImmunologyAntiviral ResponseChronic Viral Infection +4

α ₁ -Antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent

François Jean, Kori Stella, Laurel Thomas, +4

Proceedings of the National Academy of Sciences

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

Michael Köttgen, Thomas Benzing, Thomas Simmen, +13

The EMBO Journal

The Subcellular Distribution of Calnexin Is Mediated by PACS-2

Nathan Myhill, Emily M. Lynes, Jalal A. Nanji, +6

Molecular Biology of the Cell

Molecular BiologyCytoskeletonCellular PhysiologySubcellular DistributionCell Surface +16