Kurt R. Klimpel

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

Nicholas S. Duesbery, Craig P. Webb, Stephen H. Leppla et al. · Science · 1998 · 1K citations

Apoptosis, Immunology, Cell Death +19

Crystal structure of the anthrax toxin protective antigen

Carlo Petosa, R. John Collier, Kurt R. Klimpel et al. · Nature · 1997 · 754 citations

Microbial Toxin, Crystal Structure, Toxinology +4

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

Sean S. Molloy, Patricia A. Bresnahan, S H Leppla et al. · Journal of Biological Chemistry · 1992 · 690 citations · Full text

Toxin Protective Antigen, Protein Secretion, Immunology +18

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

Kurt R. Klimpel, Sean S. Molloy, Gary Thomas et al. · Proceedings of the National Academy of Sciences · 1992 · 458 citations · Full text

Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Kurt R. Klimpel, Naveen Arora, Stephen H. Leppla · Molecular Microbiology · 1994 · 309 citations